The wrist-friendly contour of the Adesso vertical mice allows you to hold your hand in a neutral "handshake position", minimizing your forearm muscles from twisting and the possible development of Carpal Tunnel Syndrome. Normally, your forearm muscles are twisted from sitting flat on the supporting surface when using a regular mouse. This "flat position" causes strains on your muscles and leads to wrist pains. This is where the Adesso Vertical Mice become helpful and provide alleviation.